ISD Investigators have secured major funds from Germany’s Federal Ministry of Research, Technology and Space (to strengthen clinician-led, translational neuroscience research. PROMISE (program for…

Stroke is a medical emergency with rapidly evolving brain injury. But unlike other organs, the brain lacks a blood test to monitor acute injury. ISD researchers and international partners report that…

Small vessel disease (SVD) is a major cause of stroke, yet its molecular drivers remain elusive. ISD researchers now show that the stroke-risk gene FOXF2 is essential for maintaining healthy brain…

Maintaining a functional blood–brain barrier (BBB) is crucial for brain function, but human models are needed to better understand human disease. ISD researchers developed a human BBB model from stem…

The European Research Council has awarded a prestigious 2-million-euro Consolidator Grant to support TRAINED, a project led by Arthur Liesz that investigates how maladaptive trained immunity drives…

The Senate of the German Research Foundation has approved funding of a new CRC on “Compartmentalized Cellular Networks in Neurovascular Diseases”. CRC 1744 aims to uncover the causes of Neurovascular…

Synapses are not only essential for information transfer but also potential gateways for the spread of pathogenic processes in the brain. A study by ISD investigators found brain regions with high…

Of the world’s population of scientists, Highly Cited Researchers™ are 1 in 1,000. The current list from Clarivate identifies researchers who demonstrated significant influence in their field through…

Organized by the ISD and Dept. of Nuclear Medicine (LMU Hospital) along with Life Molecular Imaging (LMI), a Lantheus Company, this 2-day symposium (October 16-17) unites leading researchers and…

Front line results from the DZNE-funded multicenter DEMDAS study identify metabolic syndrome and reduced HDL cholesterol as novel, modifiable risk factors for post-stroke dementia, and reveal…

A new study published in Brain, led by Nicolai Franzmeier at the ISD, shows that cortical tau deposits in Alzheimer’s disease trigger degeneration of directly connected white matter tracts. These…

The team of Marios Georgakis used an IL6 genetic instrument to mimic IL-6 inhibition in over 500,000 individuals, showing reduced risks of coronary and peripheral artery disease and ischemic stroke…

Mikael Simons receives US$500,000 for a project to investigate disease mechanisms involving so-called tau proteins. The funding is part of the international program „Tauopathy Challenge Workshop…

A multi-center study led by Nicolai Franzmeier (ISD) and Rik Ossenkoppele (Amsterdam UMC) compiled the to date largest biomarker and post-mortem dataset on atypical Alzheimer’s disease, showing…

ISD research teams met at the Ammersee for the annual scientific retreat to present their projects and discuss science. Besides presentations from Ph.D. students, a poster session, invited speaker…

Arthur Liesz received the prestigious ESO Scientific Excellence Award for his contributions to the understanding of stroke and neurovascular disease. The award was delivered in the Presidential…

The Munich Cluster for Systems Neurology (SyNergy) has been awarded a third funding period (2026-2032) by the DFG. The decision was announced on Thursday May 22nd and followed a competitive review…

Using chronic 2-photon imaging in-vivo, Anna-Sophia Wahl and her team tracked the fate of individual neurons involved in spatial memory before and after multiple, distributed microstrokes. Network…

In an effort to develop novel therapeutic strategies for the treatment of Alzheimer’s disease, ISD investigators recently were awarded a project grant on “Reprogrammed microglial cells as a…

In a collaborative study, ISD researchers found that Alpha-synuclein co-pathology is more common in advanced AD and accelerates tau aggregation and cognitive decline. This underscores the need to…

Fatty liver disease exacerbates atherosclerosis, but the mechanisms are incompletely understood. A new collaborative study led by ISD investigators identifies D-dopachrome tautomerase (D-DT/MIF-2) as…

Common genetic variants in a cis-regulatory element at HDAC9 are associated with atherosclerotic phenotypes including stroke and myocardial infarction. ISD investigators now defined a mechanism…