In a paper published in Cell, Corinne Benakis and her team report that gut bacteria able to produce indole from tryptophan are associated with poorer outcome in patients with stroke. Experiments in…

A new PET imaging approach may enable the assessment of amyloid, tau pathology, and neurodegeneration in a single scan. Using dynamic [¹⁸F]PI-2620 PET, a team of researchers including ISD…

The European Research Council has awarded a prestigious 1.5 million Euro Starting Grant to support SURPASS, a project led by clinician scientist Steffen Tiedt that investigates the biological…

ISD researcher Jule Filler received the Young Investigator Award at the European Stroke Organisation Conference (ESOC) 2026 in Maastricht for her work "Early plasma NfL predicts cognitive outcomes 5…

Dominik Paquet and his team developed a highly reproducible, iPSC-derived three-dimensional cortical brain tissue model (3BTM) containing neurons, astrocytes and microglia to investigate Alzheimer's…

Dominik Paquet and Angelika Dannert, have received this year’s prestigious Rolf Becker Prize. Their award-winning publications focus on a three-dimensional model of the human blood-brain barrier…

ISD researcher Naomi Vlegels, PhD, was nominated LMU Medical Scientist of the Year 2026. The award, which was given for her work “Brain-derived tau for monitoring brain injury in acute ischemic…

Amyloid-beta and tau are the two proteins that define Alzheimer's disease. Amyloid-beta accumulates first, and is thought to trigger the spread of tau pathology through connected brain regions over…

Blood-based biomarkers are increasingly used to support Alzheimer’s disease diagnosis, but many patients also have cerebral small vessel disease, a common vascular brain pathology. ISD researchers…

Ali Erturk and his team have developed an artificial intelligence (AI) framework that maps disease-related changes throughout the entire mouse body at cellular resolution. Using MouseMapper, the…

With the official launch of CRC 1744 we welcomed principal investigators and early career researchers as well as distinguished guest speakers to a one-day kick-off meeting. The event featured keynote…

Dominik Paquet and his team developed a human iPSC-derived neuronal model that mimics late-stage tauopathies by inducing adult-like 4R tau expression and combining disease mutations. The model…

In an international effort co-led by Steffen Tiedt, scientists from multiple disciplines have proposed research priorities and minimum reporting datasets for stroke biomarker research. The new…

February 23–25, 2026 – The second BIOSTROKE Meeting was successfully held at Schloss Hohenkammer, co-organized by ISD group leader Steffen Tiedt. Building on the success of the inaugural 2024…

ISD Investigators have secured major funds from Germany’s Federal Ministry of Research, Technology and Space to strengthen clinician-led, translational neuroscience research. PROMISE (program…

Stroke is a medical emergency with rapidly evolving brain injury. But unlike other organs, the brain lacks a blood test to monitor acute injury. ISD researchers and international partners report that…

Small vessel disease (SVD) is a major cause of stroke, yet its molecular drivers remain elusive. ISD researchers now show that the stroke-risk gene FOXF2 is essential for maintaining healthy brain…

Maintaining a functional blood–brain barrier (BBB) is crucial for brain function, but human models are needed to better understand human disease. ISD researchers developed a human BBB model from stem…

The European Research Council has awarded a prestigious 2-million-euro Consolidator Grant to support TRAINED, a project led by Arthur Liesz that investigates how maladaptive trained immunity drives…

The Senate of the German Research Foundation has approved funding of a new CRC on “Compartmentalized Cellular Networks in Neurovascular Diseases”. CRC 1744 aims to uncover the causes of Neurovascular…

Synapses are not only essential for information transfer but also potential gateways for the spread of pathogenic processes in the brain. A study by ISD investigators found brain regions with high…

Of the world’s population of scientists, Highly Cited Researchers™ are 1 in 1,000. The current list from Clarivate identifies researchers who demonstrated significant influence in their field through…