We are very proud of Judit Gonzalez Gallego, who successfully defended her great PhD work co-supervised by Martin Dichgans and Dominik. Congratulations Judit and many thanks for your nice work! And thanks lab for the wonderful hat!

We are delighted to receive a research grant from the German Ministry for Education and Research BMBF for a collaboration with ISAR Bioscience GmbH on our human iPSC-based brain tissue models for Alzheimer’s disease! Many thanks for the support. For further info, see here...

We are very happy that we could contribute to a study in Molecular Neurodegeneration: A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controls. Great collaboration with the labs of Christian Haass and Stefan Lichtenthaler at DZNE and Henrik Zetterberg at Uni Gothenburg! Congrats Ida!

Dominik presented our work at the Endolysosomal x Neuroimmune Consortium Meeting in Gloucester, USA. And he also helped eating all the leftover lobster...

Dominik was invited to present the Keynote lecture at the PORT for Health Neuroscience meeting in Wroclaw, Poland. Thanks for the invitation!

We are delighted to receive a prestigious research grant from the Alzheimer’s Association for the E2A program for our project on investigating molecular disease mechanism in a human model of FTD-GRN. Many thanks! For further info, see here...

We just posted a preprint on BioRxiv: Rescue of FTLD-associated TDP-43 pathology and neurodegeneration by peripheral AAV-mediated expression of brain-penetrant progranulin. Great collaboration with the labs of Christian Haass at DZNE and Gil di Paolo at DENALI Inc.! Congrats Marvin and Matt!

We are very proud of Sophie Robinson, who successfully defended her nice PhD work co-supervised by Christian Haass and Dominik. Congratulations Sophie and good luck with your new job in Boston! And thanks lab for the wonderful hat!

We had again a great time at the ISD retreat and Carolina presented her project.

Dominik presented Judit’s work in a talk at the CVB Neurovascular Meeting in Uppsala, Sweden.

We just posted a preprint on BioRxiv: A MICROGLIAL ACTIVITY STATE BIOMARKER PANEL DIFFERENTIATES FTD-GRANULIN AND AD FROM CONTROL CASES. Great collaboration with the labs of Christian Haass and Stefan Lichtenthaler at DZNE and Henrik Zetterberg at Uni Gotherburg! Congrats Ida!

New research paper from the lab at STAR Protocols: Reproducible and scalable differentiation of highly pure cortical neurons from human induced pluripotent stem cells. We hope our reproducible neuron differentiation protcol will be useful for the field! Congrats Angelika, Julien and Carolina!

Congratulations to Joey Kroeger, who successfully defended his PhD work! Thanks for your work and best of luck for your new job in Planegg! And thanks lab for the wonderful hat!

We are very happy that we could contribute to a study in JBC: Membrane lipid remodeling modulates γ-secretase processivity. Great collaboration with Harald Steiner at LMU/DZNE Munich. Congrats Edgar!

Dominik presented Angelika’s work at the AD/PD 2023 conference in Gothenburg, Sweden.

We are very happy that we could contribute to a study in Nature Biotechnology: Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia. Great collaboration with Sebastian Kobold from LMU Hospital. Congrats Adrian!

Judit and Dominik joined the first meeting of our new Leducq network in NYC to present and discuss our work and set up some nice collaborations.

Congratulations to Liliana Pedro Dominguez, who successfully defended her PhD co-supervised by Mika Simons and Dominik! Thanks for your nice work and best of luck for your new job in Hamburg! And thanks lab for the wonderful hat!

We are delighted to receive a prestigious research grant from Foundation Leducq for our collaborative project BRENDA - International Network of Excellence on Brain Endothelium - A Nexus for Cerebral Small Vessel Disease. For further info, see https://www.brenda-leducq.de

We had a funny Christmas party in our institute!

We are very happy that we could contribute to a study in Cell Stem Cell “A reference human induced pluripotent stem cell line for large-scale collaborative studies“. Great collaboration with Florian Merkle, Michael Ward, Mark Cookson and Bill Skarnes! Congrats Caroline et al.!

Judit presented her work at the EMBO Neurovascular interface meeting in Heidelberg in a talk.

Several lab members joined the International Eibsee Conference to present our work and exchange ideas.

Get-together to welcome the newest Baby-lab-member!

Dominik presented our work at the International ISMND Conference in Athens, Greece and received an award for the best talk. Many thanks for selecting our work!

We are very proud of Julien Klimmt, who defended his great PhD work successfully. Congratulations Julien and many thanks for your nice work! And thanks lab for the wonderful hat!

The lab joined the Oktoberfest lecture with special guest Matt Blurton-Jones. Thanks, Matt, for coming and enjoying the “Wiesn” with us.

New research paper from the lab in EMBO Molecular Medicine: TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann–Pick type C1, and Batten disease. Great collaboration with Diego Medina and Christian Grimm! Congrats Anna and Einar!

The lab was again very strong at b2run 2022, a running event of Munich companies and institutes.

We hosted Martin Kampmann from UCSF for a research talk, discussions with lab members, and a “PI hike” around Zugspitze. Thanks, Martin, for visiting us!

We had a nice and scientifically stimulating ISD retreat at Ammersee.

Judit and Dominik joined a fantastic workshop “Mechanism of Cerebral Small Vessel Disease” in Crans-Montana, Switzerland, for extended discussions with leaders in the field.

Several lab members attended the 2022 Stem Cell Workshop in Tübingen, Germany. Dominik presented a research talk and Julien and Angelika posters. Big congrats to Angelika for winning the best poster award!

We are delighted to receive a research grant on our human iPSC-based model of Tauopathies from the Brightfocus Foundation! Many thanks for your support!

Sophie and Julien presented posters at the international AD/PD meeting in Barcelona, and Dominik chaired a session and presented several cool lab projects in a talk.

New research paper from the lab in The EMBO Journal: Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. Great collaboration with the labs of Christian Haass at DZNE and Kathryn Monroe at DENALI Inc.! Congrats Annika and Sophie!

We had a small socially distanced lab get together and got an exciting tour of the technical parts of our research building.

Two posters from the lab at #NHAD21 in Leuven from @JulienKlimmt and @AngelikaDannert about our iPSC-derived models of Alzheimer’s and Tauopathies.

Dominik presented our work on iPSC-derived human brain tissue models of neurodegenerative and neurovascular diseases at the German stem cell conference #GSCN21 

We are very happy that we could contribute to a study in EMBO Molecular Medicine: Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype. Great collaboration with Diego Medina and Christian Grimm! Congrats Chiara!

We made a very nice (and long overdue…) lab trip by bike to Lake Starnberg with Pizza, beach volleyball and swimming - beautiful and warm day!

We are really excited and happy that one the lab’s first PhD students successfully defended her thesis! Big congrats Isabel Weisheit and all the best for your future (and thanks lab for the fantastic hat…)!

We just posted a preprint on BioRxiv: Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology. Great collaboration with the labs of Christian Haass at DZNE and Kathryn Monroe at DENALI Inc.! Congrats Annika and Sophie!