Paquet Lab News Archive

Dominik visited Dirk Busch and colleagues at TUM Institute for Immunology in Munich for a talk and discussions about CRISPR genome editing.

We had a great night at the Oktoberfest in Munich - everyone had a lot of fun!

Dominik joined the Meeting of the German Society for Biochemistry and Molecular Biology in Marburg to talk about our most recent work in CRISPR genome editing and iPSC disease modeling! Thanks GBM for the invitation!

We just finished our first molecular neurobiology course for the GSN - Graduate school of Systemic Neurosciences. The students learned how to turn human iPSCs into cortical neurons and took a couple of cool pictures of their cells. Looking forward to next year!

We had our first PaquetLab barbecue! It was a great night with steaks, drinks and star-gazing :-)

Go @PaquetLab! We had great fun with 40.000 other runners at the Olympic stadium in Munich at b2run, one of the biggest running events for company teams in Germany, and we supported the winning team of our LMU University hospital.

Isabel and Julien received awards for the beautiful images they submitted to the photo competition at the ISD retreat in Herrsching, Germany. Congrats!

Congratulations to Isabel on her selection for the GSN – Graduate School of Systemic Neurosciences

Dominik visited the Instituto de Technologia Quimica e Biologica in Lisbon to help with a PhD defense and give a talk about CRISPR genome editing. Many thanks to Catarina Brito and Claudia Almeida for the kind invitation! 

Sarah and Johannes joined the PaquetLab for research projects on neurodegenerative and neurovascular disorders, welcome!

Dominik our work on genome editing and Alzheimer disease modeling in iPSCs at the CTERP translational research in cell therapy meeting in Moscow, Russia.

Judit joined the PaquetLab for an undergraduate research project on CRISPR/Cas9 genome editing, welcome! 

Dennis joins the PaquetLab as BTA and will support us in multiple ways in the cell culture and general lab. Welcome aboard Dennis!

Dominik presented our work at the The seventeenth Eibsee Meeting on Cellular Mechanisms of Neurodegeneration.

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Our work on improving HDR efficiency for CRISPR Editing is featured on the Addgene Blog. Thanks to Dylan Kwart at The Rockefeller University and Tyler Ford at Addgene for the nice collaboration.

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After several weeks of construction, we opened our new stem cell research facility at the CSD building. The new lab provides ideal conditions to grow and characterize novel human brain tissue models derived from patient stem cells, to investigate molecular mechanisms of dementia, stroke and related diseases.

Dominik presents our work at the EMBO Mechanisms of Neurodegeneration Meeting in Heidelberg, Germany.

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Congratulations to Julien on his selection for the GSN – Graduate School of Systemic Neurosciences.

Welcome to Julien, who also joined the lab as a graduate student - we look forward to working with you!

Welcome to Isabel, who joined the lab as a graduate student - we look forward to working with you!

Dominik Paquet

Coming from The Rockefeller University (New York, USA), Dominik Paquet has joined the ISD. He was appointed Professor for Neurobiology and is a member of the Munich Cluster for Systems Neurology (SyNergy). Following his PhD at the LMU Munich, Prof. Paquet worked as a New York Stem Cell Foundation Druckenmiller Fellow in the laboratory of Marc Tessier-Lavigne, where he pioneered the use of CRISPR/Cas9 gene editing in induced pluripotent stem cells to study diseases of the human brain. His research at the ISD will center on the molecular and cellular mechanisms leading to neuronal death and cognitive decline in patients with neuropsychiatric disorders (e.g. Alzheimer’s disease and Frontotemporal dementia) and neurovascular impairments (stroke and vascular cognitive impairment). He plans to build advanced human in vitro model systems based on patient-derived cells that recapitulate major disease hallmarks, and thus facilitate molecular studies and accelerate the identification of novel therapeutic approaches.

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