A proteomic profiling study on brain endothelial cells (BEC) by ISD investigators reveals a dysregulation of key regulators of endocytosis and receptor recycling (most prominently Arf6), macropinocytosis, and lysosomal degradation during aging. The study identified changes undetected in transcriptomic studies such as an accumulation of vesicle cargo and receptor ligands including Apoe.

Data are accessible via an interactive database https://becaging.de/

Todorov-Völgyi K, González-Gallego J, Müller SA, Beaufort N, Malik R, Schifferer M, Todorov MI, Crusius D, Robinson S, Schmidt A, Körbelin J, Bareyre F, Ertürk A, Haass C, Simons M, Paquet D, Lichtenthaler SF, Dichgans M. Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging. Nat Aging. 2024 Apr;4(4):595-612. doi: 10.1038/s43587-024-00598-z. Epub 2024 Mar 22.