LMU Munich University Hospital
  • Our Labs
      Dichgans Lab
        Bernhagen Lab
          Simons Lab
            Liesz Lab
              Ewers Lab
                Paquet Lab
                  Plesnila Lab
                    Erturk Lab
                      Wahl Lab
                        Duering Lab
                          Benakis Lab
                            Franzmeier Lab
                              Georgakis Lab
                                Jäkel Lab
                                  Spitzer Lab
                                    Tiedt Lab
                                  • News
                                  • Publications
                                  • About us
                                      How to get there
                                        Scientific Advisory Board
                                          Management
                                            Media 
                                              Diversity at the ISD
                                                ISD Photos 
                                              • Funding
                                              • Open positions
                                              • For Patients
                                              1. ISD Research
                                              2. News
                                              3. test page

                                              test page

                                              New Publications

                                              Innate immune memory after stroke mediates secondary comorbidities. 

                                              22 Jul 2024

                                              ISD researchers hypothesized in a newly published study that the high rate of comorbidities that develop after a stroke could have a common immunological cause. A Myeloid innate immune memory was…

                                              Rational correction of disease-causing mutations in HTRA1

                                              17 Jul 2024

                                              Rare mutations in HTRA1 cause cerebral vasculopathy and stroke. Using in vitro, in silico and in vivo analyses, the Dichgans lab in collaboration with colleagues from Duisburg established…

                                              Rare and common HTRA1 variants affect stroke risk via two independent mechanisms

                                              5 May 2024

                                              Combining genetic analyses in large international biobanks with experimental studies on human cells, ISD investigators found that rare HTRA1 variants affect vascular risk via a loss of enzymatic…

                                              News

                                              October 15-17: 9th ICAA Conference in Munich

                                              July 2024 – ISD is co-organizing the 9th Interational Conference on Cerebral Amyloid Angiopathy located at the Kardinal Wendel Haus next to the English Garden in Munich. Experts in the field will present the latest developments in CAA research ranging from basic research to studies in humans. 

                                              To take part sign up now here >>

                                              ISD Research Retreat

                                              July 2024 – ISD research teams gathered for the annual scientific retreat to present their projects and discuss science. The meeting included presentations from Ph.D. students, an evening poster session, invited speaker talks, and a three minute thesis competition. The meeting further served as an opportunity to familiarize people with the medium- and long-term strategy of ISD.

                                              Research Groups

                                              martin-dichgans-research-group-visual

                                              Dichgans Lab

                                              Translational Research – Martin Dichgans

                                              mif atherosclotic lesion.jpg

                                              Bernhagen Lab

                                              Vascular Biology – Jürgen Bernhagen

                                              Simons Lab

                                              Biology of Glia and Neuro­inflammation – Mikael Simon

                                              Liesz Lab

                                              Stroke-Immunology –  Arthur Liesz

                                              Ewers Lab

                                              Brain Imaging and Biomarker – Michael Ewers

                                              paquet cells

                                              Paquet Lab

                                              Neurodegeneration and Vascular Dysfunction – Dominik Paquet

                                              ISD

                                              Plesnila Lab

                                              Experimental Stroke Research – Nikolaus Plesnila

                                              Erturk Lab

                                              Acute Brain Injury – Ali Erturk

                                              Wahl Lab

                                              Neuronal Repair and Rewiring – Anna-Sophia Wahl 

                                              Düring Lab

                                              Vascular Cognitive Impairment – Marco Düring

                                              Gokce Visual

                                              Gokce Lab

                                              Systems Neuroscience –  Ozgun Gokce

                                              Junior Research Groups

                                              benakis

                                              Benakis Lab

                                              Microbiome-Gut-Brain Axis – Corinne Benakis

                                              Franzmeier Lab

                                              Alzheimer’s Disease Neuroimaging  – Nicolai Franzmeier

                                              Georgakis Lab

                                              Epidemiology and Bioinformatics – Marios Georgakis

                                              Jäkel Lab

                                              Jäkel Lab

                                              Oligodendrocyte Pathology – Sarah Jäkel

                                              Machine learning and data science 

                                              Spitzer Lab

                                              Machine learning and data science – Hannah Spitzer

                                              Tiedt

                                              Tiedt Lab

                                              Molecular Biomarkers – Steffen Tiedt

                                              The risk of early recurrent events after stroke remains high, especially in patients with atherosclerosis.

                                              August 2024 –  Using a novel mouse model, ISD researchers showed stroke activates the AIM2 inflammasome in atherosclerotic plaques via increased circulating cell-free DNA, causing inflammation, plaque destabilization, and recurrent stroke. Neutrophil NETosis was identified as the main source of cell-free DNA. Neutralizing cell-free DNA or inhibiting inflammasome activation reduced stroke recurrence, highlighting new therapeutic targets to prevent early recurrent events >>

                                              news feed widget:

                                              news selected teasers 

                                              publications:

                                              DNA-sensing inflammasomes cause recurrent atherosclerotic stroke

                                              8 Aug 2024

                                              Using a novel experimental model, ISD researchers showed that stroke activates the AIM2 inflammasome in atherosclerotic plaques via increased circulating cell-free DNA, causing inflammation, plaque…

                                              Innate immune memory after stroke mediates secondary comorbidities. 

                                              22 Jul 2024

                                              ISD researchers hypothesized in a newly published study that the high rate of comorbidities that develop after a stroke could have a common immunological cause. A Myeloid innate immune memory was…

                                              Rational correction of disease-causing mutations in HTRA1

                                              17 Jul 2024

                                              Rare mutations in HTRA1 cause cerebral vasculopathy and stroke. Using in vitro, in silico and in vivo analyses, the Dichgans lab in collaboration with colleagues from Duisburg established…

                                              news selected teasers 

                                              general news

                                              Register now! October 15-17: 9th ICAA Conference in Munich

                                              10 Jul 2024

                                              ISD is co-organizing the 9th Interational Conference on Cerebral Amyloid Angiopathy located at the Kardinal Wendel Haus next to the English Garden in Munich. Experts in the field will present the…

                                              Antonia Weingart

                                              ISD Research Retreat

                                              4 Jul 2024

                                              ISD research teams gathered for the annual scientific retreat to present their projects and discuss science. The meeting included presentations from Ph.D. students, an evening poster session, invited…

                                              SMN

                                              International Review by the ISD Scientific Advisory Board

                                              20 Jun 2024

                                              Every two years, an international committee of scientific advisors evaluates ISD's research activities and makes recommendations for future direction. The first day of the meeting was dedicated to an…

                                              New Publications

                                              Innate immune memory after stroke mediates secondary comorbidities. 

                                              22 Jul 2024

                                              ISD researchers hypothesized in a newly published study that the high rate of comorbidities that develop after a stroke could have a common immunological cause. A Myeloid innate immune memory was…

                                              Rational correction of disease-causing mutations in HTRA1

                                              17 Jul 2024

                                              Rare mutations in HTRA1 cause cerebral vasculopathy and stroke. Using in vitro, in silico and in vivo analyses, the Dichgans lab in collaboration with colleagues from Duisburg established…

                                              Rare and common HTRA1 variants affect stroke risk via two independent mechanisms

                                              5 May 2024

                                              Combining genetic analyses in large international biobanks with experimental studies on human cells, ISD investigators found that rare HTRA1 variants affect vascular risk via a loss of enzymatic…

                                              News

                                              Register now! October 15-17: 9th ICAA Conference in Munich

                                              10 Jul 2024

                                              ISD is co-organizing the 9th Interational Conference on Cerebral Amyloid Angiopathy located at the Kardinal Wendel Haus next to the English Garden in Munich. Experts in the field will present the…

                                              International Review by the ISD Scientific Advisory Board

                                              20 Jun 2024

                                              Every two years, an international committee of scientific advisors evaluates ISD's research activities and makes recommendations for future direction. The first day of the meeting was dedicated to an…

                                              October 15-17: 9th ICAA Conference in Munich

                                              July 2024 – ISD is co-organizing the 9th Interational Conference on Cerebral Amyloid Angiopathy located at the Kardinal Wendel Haus next to the English Garden in Munich. Experts in the field will present the latest developments in CAA research ranging from basic research to studies in humans. To take part sign up now here >>

                                              ISD Research Retreat

                                              July 2024 – ISD research teams gathered for the annual scientific retreat to present their projects and discuss science. The meeting included presentations from Ph.D. students, an evening poster session, invited speaker talks, and a three minute thesis competition. The meeting further served as an opportunity to familiarize people with the medium- and long-term strategy of ISD.

                                              Research Groups

                                              martin-dichgans-research-group-visual

                                              Dichgans Lab

                                              Translational Research – Martin Dichgans

                                              mif atherosclotic lesion.jpg

                                              Bernhagen Lab

                                              Vascular Biology – Jürgen Bernhagen

                                              Simons Lab

                                              Biology of Glia and Neuro­inflammation – Mikael Simon

                                              Liesz Lab

                                              Stroke-Immunology –  Arthur Liesz

                                              Ewers Lab

                                              Brain Imaging and Biomarker – Michael Ewers

                                              paquet cells

                                              Paquet Lab

                                              Neurodegeneration and Vascular Dysfunction – Dominik Paquet

                                              ISD

                                              Plesnila Lab

                                              Experimental Stroke Research – Nikolaus Plesnila

                                              Erturk Lab

                                              Acute Brain Injury – Ali Erturk

                                              Wahl Lab

                                              Neuronal Repair and Rewiring – Anna-Sophia Wahl 

                                              Düring Lab

                                              Vascular Cognitive Impairment – Marco Düring

                                              Gokce Visual

                                              Gokce Lab

                                              Systems Neuroscience –  Ozgun Gokce

                                              Junior Research Groups

                                              benakis

                                              Benakis Lab

                                              Microbiome-Gut-Brain Axis – Corinne Benakis

                                              Franzmeier Lab

                                              Alzheimer’s Disease Neuroimaging  – Nicolai Franzmeier

                                              Georgakis Lab

                                              Epidemiology and Bioinformatics – Marios Georgakis

                                              Jäkel Lab

                                              Jäkel Lab

                                              Oligodendrocyte Pathology – Sarah Jäkel

                                              Machine learning and data science 

                                              Spitzer Lab

                                              Machine learning and data science – Hannah Spitzer

                                              Tiedt

                                              Tiedt Lab

                                              Molecular Biomarkers – Steffen Tiedt

                                              Panel 1
                                              Panel 2

                                              Contact

                                              Institute for Stroke and Dementia Research (ISD)
                                              University Hospital, LMU Munich

                                              Director: Prof. Dr. med. Martin Dichgans

                                              Feodor-Lynen-Straße 17
                                              81377 Munich, Germany

                                              Phone: +49 (0)89 4400 46019
                                              www.isd-research.de

                                              Send a Mail

                                              Partners

                                              Neurologische Klinik und Poliklinik der Universität München, LMU Klinikum

                                              DZNE – Deutsches Zentrum für Neurodegenerative Erkrankungen

                                              SyNergy – Munich Cluster for Systems Neurology

                                              Links

                                              • Our Labs
                                              • News
                                              • Publications
                                              • Open Positions
                                              • ISD for Patients
                                              • How to get there
                                              • Imprint
                                              Login for editors
                                              • Contact
                                              • Imprint
                                              • Privacy Policy
                                              2025 © Institute for Stroke and Dementia Research (ISD)
                                            • LMU Munich
                                            • University Hospital
                                            • ISD Research

                                              • Our Labs
                                                • Dichgans Lab
                                                • Bernhagen Lab
                                                • Simons Lab
                                                • Liesz Lab
                                                • Ewers Lab
                                                • Paquet Lab
                                                • Plesnila Lab
                                                • Erturk Lab
                                                • Wahl Lab
                                                • Duering Lab
                                                • Benakis Lab
                                                • Franzmeier Lab
                                                • Georgakis Lab
                                                • Jäkel Lab
                                                • Spitzer Lab
                                                • Tiedt Lab
                                              • News
                                              • Publications
                                              • About us
                                                • How to get there
                                                • Scientific Advisory Board
                                                • Management
                                                • Media 
                                                • Diversity at the ISD
                                                • ISD Photos 
                                              • Funding
                                              • Open positions
                                              • For Patients