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New Publications

Innate immune memory after stroke mediates secondary comorbidities. 

22 Jul 2024

ISD researchers hypothesized in a newly published study that the high rate of comorbidities that develop after a stroke could have a common immunological cause. A Myeloid innate immune memory was…

Rational correction of disease-causing mutations in HTRA1

17 Jul 2024

Rare mutations in HTRA1 cause cerebral vasculopathy and stroke. Using in vitro, in silico and in vivo analyses, the Dichgans lab in collaboration with colleagues from Duisburg established…

Rare and common HTRA1 variants affect stroke risk via two independent mechanisms

5 May 2024

Combining genetic analyses in large international biobanks with experimental studies on human cells, ISD investigators found that rare HTRA1 variants affect vascular risk via a loss of enzymatic…

News

October 15-17: 9th ICAA Conference in Munich

July 2024 – ISD is co-organizing the 9th Interational Conference on Cerebral Amyloid Angiopathy located at the Kardinal Wendel Haus next to the English Garden in Munich. Experts in the field will present the latest developments in CAA research ranging from basic research to studies in humans. 

To take part sign up now here >>

ISD Research Retreat

July 2024 – ISD research teams gathered for the annual scientific retreat to present their projects and discuss science. The meeting included presentations from Ph.D. students, an evening poster session, invited speaker talks, and a three minute thesis competition. The meeting further served as an opportunity to familiarize people with the medium- and long-term strategy of ISD.

Research Groups

martin-dichgans-research-group-visual

Dichgans Lab

Translational Research – Martin Dichgans

mif atherosclotic lesion.jpg

Bernhagen Lab

Vascular Biology – Jürgen Bernhagen

Simons Lab

Biology of Glia and Neuro­inflammation – Mikael Simon

Liesz Lab

Stroke-Immunology –  Arthur Liesz

Ewers Lab

Brain Imaging and Biomarker – Michael Ewers

paquet cells

Paquet Lab

Neurodegeneration and Vascular Dysfunction – Dominik Paquet

ISD

Plesnila Lab

Experimental Stroke Research – Nikolaus Plesnila

Erturk Lab

Acute Brain Injury – Ali Erturk

Wahl Lab

Neuronal Repair and Rewiring – Anna-Sophia Wahl 

Düring Lab

Vascular Cognitive Impairment – Marco Düring

Gokce Visual

Gokce Lab

Systems Neuroscience –  Ozgun Gokce

Junior Research Groups

benakis

Benakis Lab

Microbiome-Gut-Brain Axis – Corinne Benakis

Franzmeier Lab

Alzheimer’s Disease Neuroimaging  – Nicolai Franzmeier

Georgakis Lab

Epidemiology and Bioinformatics – Marios Georgakis

Jäkel Lab

Jäkel Lab

Oligodendrocyte Pathology – Sarah Jäkel

Machine learning and data science 

Spitzer Lab

Machine learning and data science – Hannah Spitzer

Tiedt

Tiedt Lab

Molecular Biomarkers – Steffen Tiedt

The risk of early recurrent events after stroke remains high, especially in patients with atherosclerosis.

August 2024 –  Using a novel mouse model, ISD researchers showed stroke activates the AIM2 inflammasome in atherosclerotic plaques via increased circulating cell-free DNA, causing inflammation, plaque destabilization, and recurrent stroke. Neutrophil NETosis was identified as the main source of cell-free DNA. Neutralizing cell-free DNA or inhibiting inflammasome activation reduced stroke recurrence, highlighting new therapeutic targets to prevent early recurrent events >>

news feed widget:

news selected teasers 

publications:

DNA-sensing inflammasomes cause recurrent atherosclerotic stroke

8 Aug 2024

Using a novel experimental model, ISD researchers showed that stroke activates the AIM2 inflammasome in atherosclerotic plaques via increased circulating cell-free DNA, causing inflammation, plaque…

Innate immune memory after stroke mediates secondary comorbidities. 

22 Jul 2024

ISD researchers hypothesized in a newly published study that the high rate of comorbidities that develop after a stroke could have a common immunological cause. A Myeloid innate immune memory was…

Rational correction of disease-causing mutations in HTRA1

17 Jul 2024

Rare mutations in HTRA1 cause cerebral vasculopathy and stroke. Using in vitro, in silico and in vivo analyses, the Dichgans lab in collaboration with colleagues from Duisburg established…

news selected teasers 

general news

Register now! October 15-17: 9th ICAA Conference in Munich

10 Jul 2024

ISD is co-organizing the 9th Interational Conference on Cerebral Amyloid Angiopathy located at the Kardinal Wendel Haus next to the English Garden in Munich. Experts in the field will present the…

Antonia Weingart

ISD Research Retreat

4 Jul 2024

ISD research teams gathered for the annual scientific retreat to present their projects and discuss science. The meeting included presentations from Ph.D. students, an evening poster session, invited…

SMN

International Review by the ISD Scientific Advisory Board

20 Jun 2024

Every two years, an international committee of scientific advisors evaluates ISD's research activities and makes recommendations for future direction. The first day of the meeting was dedicated to an…

New Publications

Innate immune memory after stroke mediates secondary comorbidities. 

22 Jul 2024

ISD researchers hypothesized in a newly published study that the high rate of comorbidities that develop after a stroke could have a common immunological cause. A Myeloid innate immune memory was…

Rational correction of disease-causing mutations in HTRA1

17 Jul 2024

Rare mutations in HTRA1 cause cerebral vasculopathy and stroke. Using in vitro, in silico and in vivo analyses, the Dichgans lab in collaboration with colleagues from Duisburg established…

Rare and common HTRA1 variants affect stroke risk via two independent mechanisms

5 May 2024

Combining genetic analyses in large international biobanks with experimental studies on human cells, ISD investigators found that rare HTRA1 variants affect vascular risk via a loss of enzymatic…

News

Register now! October 15-17: 9th ICAA Conference in Munich

10 Jul 2024

ISD is co-organizing the 9th Interational Conference on Cerebral Amyloid Angiopathy located at the Kardinal Wendel Haus next to the English Garden in Munich. Experts in the field will present the…

International Review by the ISD Scientific Advisory Board

20 Jun 2024

Every two years, an international committee of scientific advisors evaluates ISD's research activities and makes recommendations for future direction. The first day of the meeting was dedicated to an…

October 15-17: 9th ICAA Conference in Munich

July 2024 – ISD is co-organizing the 9th Interational Conference on Cerebral Amyloid Angiopathy located at the Kardinal Wendel Haus next to the English Garden in Munich. Experts in the field will present the latest developments in CAA research ranging from basic research to studies in humans. To take part sign up now here >>

ISD Research Retreat

July 2024 – ISD research teams gathered for the annual scientific retreat to present their projects and discuss science. The meeting included presentations from Ph.D. students, an evening poster session, invited speaker talks, and a three minute thesis competition. The meeting further served as an opportunity to familiarize people with the medium- and long-term strategy of ISD.

Research Groups

martin-dichgans-research-group-visual

Dichgans Lab

Translational Research – Martin Dichgans

mif atherosclotic lesion.jpg

Bernhagen Lab

Vascular Biology – Jürgen Bernhagen

Simons Lab

Biology of Glia and Neuro­inflammation – Mikael Simon

Liesz Lab

Stroke-Immunology –  Arthur Liesz

Ewers Lab

Brain Imaging and Biomarker – Michael Ewers

paquet cells

Paquet Lab

Neurodegeneration and Vascular Dysfunction – Dominik Paquet

ISD

Plesnila Lab

Experimental Stroke Research – Nikolaus Plesnila

Erturk Lab

Acute Brain Injury – Ali Erturk

Wahl Lab

Neuronal Repair and Rewiring – Anna-Sophia Wahl 

Düring Lab

Vascular Cognitive Impairment – Marco Düring

Gokce Visual

Gokce Lab

Systems Neuroscience –  Ozgun Gokce

Junior Research Groups

benakis

Benakis Lab

Microbiome-Gut-Brain Axis – Corinne Benakis

Franzmeier Lab

Alzheimer’s Disease Neuroimaging  – Nicolai Franzmeier

Georgakis Lab

Epidemiology and Bioinformatics – Marios Georgakis

Jäkel Lab

Jäkel Lab

Oligodendrocyte Pathology – Sarah Jäkel

Machine learning and data science 

Spitzer Lab

Machine learning and data science – Hannah Spitzer

Tiedt

Tiedt Lab

Molecular Biomarkers – Steffen Tiedt

Panel 1
Panel 2

Contact

Institute for Stroke and Dementia Research (ISD)
University Hospital, LMU Munich

Director: Prof. Dr. med. Martin Dichgans

Feodor-Lynen-Straße 17
81377 Munich, Germany

Phone: +49 (0)89 4400 46019
www.isd-research.de

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Neurologische Klinik und Poliklinik der Universität München, LMU Klinikum

DZNE – Deutsches Zentrum für Neurodegenerative Erkrankungen

SyNergy – Munich Cluster for Systems Neurology

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